The most common place to customize your ShipStream settings is from within the System > Configuration page. This area contains settings for these main categories in the left side menu:
Within each category there are sub-categories which can be clicked to adjust their settings. By clicking the sub-category item, a new set of option tabs will appear in the main content. These tabs can be expanded by clicking the headers.
Configurations can be specified at the Merchant, Store, Warehouse or Global level using the Current Configuration Scope selection menu.